This study examines individuals with Chronic Itching with no known source (CPUO). This study takes place over 36 weeks with 5 required visits (although more visits may be necessary). Individuals within the study will be compensated for time and travel. For more information about the study and/or qualifications, contact the Asthma and Allergy Center, 402-592-2055 and ask for research or follow the “apply now” steps.